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NICE guidance on obesity (CG189) recognises that sustained weight loss of 5-10% can improve cardiovascular risk factors, glycaemic control in diabetes, and other obesity-related conditions

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Upon activation, ACSL4 catalyzes the binding of CoA to PUFAs such as arachidonic acid and adrenic acid through LPCAT3, forming acyl-CoA and participating in lipid signaling during ferroptosis

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These cells have GLP-1 receptors